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Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands.
Fraioli, R; Neubauer, S; Rechenmacher, F; Bosch, B M; Dashnyam, K; Kim, J-H; Perez, R A; Kim, H-W; Gil, F J; Ginebra, M P; Manero, J M; Kessler, H; Mas-Moruno, C.
Affiliation
  • Fraioli R; Biomaterials, Biomechanics and Tissue Engineering Group, Dept. of Materials Science and Metallurgy, Universitat Politècnica de Catalunya, Barcelona, Spain. jose.maria.manero@upc.edu carles.mas.moruno@upc.edu.
Biomater Sci ; 7(4): 1281-1285, 2019 Mar 26.
Article in En | MEDLINE | ID: mdl-30735211
ABSTRACT
In this communication we report that anchoring αvß3 or α5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Biocompatible Materials / Bone and Bones / Peptidomimetics / Mesenchymal Stem Cells Limits: Animals Language: En Journal: Biomater Sci Year: 2019 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Biocompatible Materials / Bone and Bones / Peptidomimetics / Mesenchymal Stem Cells Limits: Animals Language: En Journal: Biomater Sci Year: 2019 Document type: Article